Finding the Golgi: Golgin Coiled-Coil Proteins Show the Way.
Trends Cell Biol
; 26(6): 399-408, 2016 06.
Article
em En
| MEDLINE
| ID: mdl-26972448
ABSTRACT
The Golgi apparatus lies at the centre of the secretory pathway. It consists of a series of flattened compartments typically organised into a stack that, in mammals, is connected to additional stacks to form a Golgi ribbon. The Golgi is responsible for the maturation and modification of proteins and lipids, and receives and exports vesicles to and from multiple destinations within the cell. This complex trafficking network requires that only the correct vesicles fuse with the correct destination membrane. Recently, a group of coiled-coil proteins called golgins were shown to not only capture incoming vesicles but to also provide specificity to the tethering step. This raises many interesting questions about how they interact with other components of membrane traffic, some of which may also contribute to specificity.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Complexo de Golgi
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article