Association between -174 G/C polymorphism of interleukin-6 gene and alcoholism.
Acta Neuropsychiatr
; 15(5): 257-61, 2003 Oct.
Article
em En
| MEDLINE
| ID: mdl-26983653
ABSTRACT
OBJECTIVES:
IL-6 plays the role as a physiological neuromodulator involved in dopaminergic, serotonergic and other neurotransmissions. The aim of the present association study was to examine the effect of the G/C -174 polymorphism of the IL-6 gene on disposition to alcoholism.METHODS:
We investigated the relationship between the G/C -174 polymorphism of the IL-6 gene and alcohol dependence in 281 alcoholics and 242 control subjects.RESULTS:
The significant difference in G allele frequency between alcoholic group (0.52) and control group (0.59) was found (P < 0.03).CONCLUSION:
To our knowledge, this is the first finding providing evidence for an association between alcoholism and the polymorphism of the IL-6 gene. The background of the relationship between the IL-6 gene and alcoholism is discussed.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article