Steroidal Glucosides from the Rhizomes of Tacca chantrieri and Their Inhibitory Activities of NO Production in BV2 Cells.
Nat Prod Commun
; 11(1): 45-8, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-26996017
ABSTRACT
Two new steroidal glucosides, chantriolides D and E (1 and 2), along with four known compounds, chantriolide A (3), chantriolide B (4), chantriolide C (5), and (25S)-spirost-5-en-3-ol 3-O-α-L-rhamnopyranosyl-(1-->2)-O-[α-L-rhamnopyranosyl-(1-->3)]-ß-D-glucopyranoside (6) were isolated from the rhizomes of Tacca chantrieri. Their structures were determined by 1D and 2D NMR spectroscopic and HR-ESI-MS data, as well as by comparison with reported data. Compounds 1 and 2 were found to show strong inhibitory NO effect in BV2 cells, with IC50 values of 12.45 and 59.03 µM, respectively.
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Base de dados:
MEDLINE
Assunto principal:
Microglia
/
Dioscoreaceae
/
Rizoma
/
Glucosídeos
/
Óxido Nítrico
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article