Expedient Synthesis of Furo[2,3-d][1,3]thiazinamines and Pyrano[2,3-d][1,3]thiazinamines from Enones and Thiourea.
J Org Chem
; 81(8): 3386-90, 2016 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-27002691
ABSTRACT
Michael addition of thiourea to enones with subsequent intramolecular aminal ether formation provided easy access to furo[2,3-d]thiazinamines and pyrano[2,3-d][1,3]thiazin-2-amines. These amines served as versatile intermediates to a variety of beta-amyloid cleaving enzyme-1 (BACE1) inhibitors.
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MEDLINE
Idioma:
En
Ano de publicação:
2016
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Article