Lung Function at 8 and 16 Years After Moderate-to-Late Preterm Birth: A Prospective Cohort Study.
Pediatrics
; 137(4)2016 04.
Article
em En
| MEDLINE
| ID: mdl-27009034
ABSTRACT
BACKGROUND AND OBJECTIVE:
Knowledge regarding lung function after moderately preterm birth is limited. We therefore investigated lung function at early school age and adolescence among children born moderately preterm.METHODS:
Data were used from the Swedish prospective birth cohort BAMSE (Swedish abbreviation for Children, Allergy, Milieu, Stockholm, Epidemiology study; N = 4089), with a 4.8% prevalence of moderate to late preterm birth defined as a gestational age of 32 to 36 weeks. Participants underwent spirometry at ages 8 and 16 years, and impulse oscillometry additionally at age 16 years. In total, 2621 children (149 preterm and 2472 term) provided lung function data.RESULTS:
At age 8 years, adjusted forced expiratory volume in 1 second was lower in preterm female subjects (-64 mL [95% confidence interval (CI) -118 to -10]) compared with term female subjects but not in preterm male subjects. At age 16 years, both genders in the preterm group demonstrated lower forced expiratory volume in 1 second (femalesubjects:
-116 mL [95% CI -212 to -20]; malesubjects:
-177 mL [95% CI -329 to -25]) compared with the term group. For the preterm group, impulse oscillometry demonstrated higher adjusted resistance at 5 Hz (femalesubjects:
31.3 Pa·L(-1)·s(-1) [95% CI 6.3 to 56.3]; malesubjects:
34.9 Pa·L(-1)·s(-1) [95% CI 12.0 to 57.7]) and frequency dependence of resistance (resistance at 5 and 20 Hz) for male subjects (20.9 Pa·L(-1)·s(-1) [95% CI 9.8 to 31.9]) compared with the term group.CONCLUSIONS:
Measures of airway function assessed in adolescence were reduced in children born moderate to late preterm, and no catch-up in lung function between ages 8 and 16 years was observed.
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Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Prematuro
/
Pulmão
/
Pneumopatias
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article