Plasma amino acid profile in autism spectrum disorder (ASD).
Eur Rev Med Pharmacol Sci
; 20(5): 923-9, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-27010152
ABSTRACT
OBJECTIVE:
In our study, we aimed to reveal pathophysiologic mechanisms in ASD by comparing plasma amino acid levels between patients and healthy controls while considering vitamin B12 and D levels. PATIENTS ANDMETHODS:
The study included 21 patients aged 2-18 years-old who were followed with a diagnosis autism spectrum disorder (ASD) and 21 age and sex-matched healthy children from our outpatient clinic as control group.RESULTS:
The study included 42 children and adolescents aged 2-18 years-old (19 girls and 23 boys). There were no significant differences in terms of body weight and height between the groups. We found significant differences in levels of ammonium, phosphoethanolamine, histidine, homocysteine, carnosine, methionine, cystathionine, cystine, threonine, 3-methyl histidine and phenylalanine/tyrosine ratio between patient and control groups. Both vitamin B12 and D were significantly lower in the ASD group compared to controls. In the variance analysis with vitamin B12 and D as covariates, significant differences persisted for only phosphoethanolamine (p=0.04), cystathionine (p<0.001), cystine (p=0.006) and threonine (p=0.02).CONCLUSIONS:
Further studies are needed on the amino acids that show variations in children with ASD in order to reveal their role in the etiology and therapeutic use in ASD.
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Base de dados:
MEDLINE
Assunto principal:
Transtorno do Espectro Autista
/
Aminoácidos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article