Effects of varenicline on alpha4-containing nicotinic acetylcholine receptor expression and cognitive performance in mice.

Lange-Asschenfeldt, Christian; Schäble, Sandra; Suvorava, Tatsiana; Fahimi, Ehsan Gholamreza; Bisha, Marion; Stermann, Torben; Henning, Uwe; Kojda, Georg

Lange-Asschenfeldt, Christian; Schäble, Sandra; Suvorava, Tatsiana; Fahimi, Ehsan Gholamreza; Bisha, Marion; Stermann, Torben; Henning, Uwe; Kojda, Georg.

Afiliação

Lange-Asschenfeldt C; Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. Electronic address: kn50050@lvr.de.
Schäble S; Comparative Psychology, Institute of Experimental Psychology, Heinrich-Heine-University, Düsseldorf, Germany.
Suvorava T; Department of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Fahimi EG; Department of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Bisha M; Department of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Stermann T; Department of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany; Leibniz Center for Diabetes Research, Heinrich-Heine-University, Düsseldorf, Germany.
Henning U; Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Kojda G; Department of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.

Neuropharmacology ; 107: 100-110, 2016 08.

Article em En | MEDLINE | ID: mdl-27012889

Assuntos

Encéfalo/efeitos dos fármacos; Cognição/efeitos dos fármacos; Nootrópicos/farmacologia; Receptores Nicotínicos/metabolismo; Vareniclina/farmacologia; Administração Oral; Animais; Encéfalo/metabolismo; Linhagem Celular; Cognição/fisiologia; Modelos Animais de Doenças; Relação Dose-Resposta a Droga; Avaliação Pré-Clínica de Medicamentos; Endotélio Vascular/efeitos dos fármacos; Endotélio Vascular/metabolismo; Masculino; Transtornos da Memória/tratamento farmacológico; Transtornos da Memória/metabolismo; Camundongos Endogâmicos C57BL; RNA Mensageiro/metabolismo; Reconhecimento Psicológico/efeitos dos fármacos; Reconhecimento Psicológico/fisiologia; Escopolamina

Palavras-chave

Novel object recognition; Protein upregulation; Scopolamine-induced memory impairment; Varenicline; α(4)ß(2) nicotinic acetylcholine receptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Receptores Nicotínicos / Cognição / Nootrópicos / Vareniclina Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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