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Association Between Serum Level of Hepatitis B Surface Antigen at End of Entecavir Therapy and Risk of Relapse in E Antigen-Negative Patients.
Hsu, Yao-Chun; Mo, Lein-Ray; Chang, Chi-Yang; Wu, Ming-Shiang; Kao, Jia-Horng; Wang, Wen-Lun; Yang, Tzeng-Huey; Wang, Chaur-Shine; Chiang, Ming-Feng; Chen, Chieh-Chang; Fang, Yu-Jen; Hung, Hsu-Wei; Wu, Chun-Ying; Lin, Jaw-Town.
Afiliação
  • Hsu YC; Center for Database Research, E-Da Hospital, Kaohsiung City, Taiwan; Division of Gastroenterology, E-Da Hospital, Kaohsiung City, Taiwan; School of Medicine for International Students, I-Shou University, Kaohsiung City, Taiwan; Graduate Institute of Clinical Medicine, China Medical University, Taich
  • Mo LR; Superintendent Office, Tainan Municipal Hospital, Tainan City, Taiwan.
  • Chang CY; Division of Gastroenterology, E-Da Hospital, Kaohsiung City, Taiwan.
  • Wu MS; Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan.
  • Kao JH; Graduate Institute of Clinical Medicine, National Taiwan University, Taipei City, Taiwan.
  • Wang WL; Division of Gastroenterology, E-Da Hospital, Kaohsiung City, Taiwan.
  • Yang TH; Department of Internal Medicine, Lotung Poh-Ai Hospital, Yilan County, Taiwan.
  • Wang CS; Department of Internal Medicine, Lotung Poh-Ai Hospital, Yilan County, Taiwan.
  • Chiang MF; Department of Internal Medicine, Lotung Poh-Ai Hospital, Yilan County, Taiwan.
  • Chen CC; Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan.
  • Fang YJ; Department of Medicine, National Taiwan University Hospital Yun-Lin Branch, Yunlin County, Taiwan.
  • Hung HW; Taipei Institute of Pathology, Taipei City, Taiwan.
  • Wu CY; Graduate Institute of Clinical Medicine, China Medical University, Taichung City, Taiwan; Division of Gastroenterology, Taichung Veterans General Hospital, Taichung City, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei City, Taiwan. Electronic address: chun@vgh
  • Lin JT; School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
Clin Gastroenterol Hepatol ; 14(10): 1490-1498.e3, 2016 10.
Article em En | MEDLINE | ID: mdl-27018299
BACKGROUND & AIMS: This study investigated whether serum level of hepatitis B surface antigen (HBsAg) at the end of entecavir treatment was associated with risk of relapse. METHODS: We performed a prospective multicenter study of 161 consecutive patients with chronic hepatitis B in whom the hepatitis B virus was no longer detected after 3 years or more of entecavir therapy. Treatment ended between July 1, 2011 and July 1, 2015. Patients were monitored for clinical relapse (hepatitis B virus DNA >2000 IU/mL and level of alanine aminotransferase more than 2-fold the upper limit of normal) and virologic relapse (hepatitis B virus DNA >2000 IU/mL). Outcomes were calculated using the Kaplan-Meier method and risk factors were identified by Cox proportional hazards modeling. RESULTS: Two years after therapy ended, 49.2% of patients in the entire cohort had a clinical relapse (95% confidence interval [CI], 40.9%-58.1%) and 81.7% had a virologic relapse (95% CI, 74.3%-88.0%). Among patients who were hepatitis B e antigen-negative at the end of therapy, 39.2% had a clinical relapse (95% CI, 30.3%-49.6%) and 77.4% had a virologic relapse (95% CI, 68.6%-85.2%). Serum level of HBsAg was associated with relapse in the hepatitis B e antigen-negative patients (Ptrend = .006 for clinical relapse; Ptrend = .0001 for virologic relapse). In multivariate Cox regression analysis, the hazard ratio (per log IU/mL increment) for clinical relapse was 2.47 (95% CI, 1.45-4.23) and for virologic relapse was 1.80 (95% CI, 1.33-2.45). The 11 (9%) patients with levels of HBsAg <10 IU/mL did not relapse. CONCLUSIONS: Serum level of HBsAg is associated with risk of relapse in patients who are hepatitis B e antigen-negative after treatment with entecavir. A low titer of HBsAg might be used to identify patients at low risk for relapse after treatment.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Hepatite B Crônica / Guanina / Antígenos E da Hepatite B / Antígenos de Superfície da Hepatite B Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Hepatite B Crônica / Guanina / Antígenos E da Hepatite B / Antígenos de Superfície da Hepatite B Idioma: En Ano de publicação: 2016 Tipo de documento: Article