Influence of vitamin A status and DDT on vitamin A-dependent protein mannosylation in rat liver.
Chem Biol Interact
; 69(2-3): 259-67, 1989.
Article
em En
| MEDLINE
| ID: mdl-2702705
ABSTRACT
Male Wistar rats of different vitamin A status (total depletion to moderate deficiency) were administered DDT (5 mg/kg/day) or vehicule (corn oil) i.p. daily for 14 days. Vitamin A-dependent protein mannosylation was measured either by in vivo incorporation of [3H]mannose into liver glycoprotein or by in vitro assay of incorporation of [14C]mannose into mannosylretinyl phosphate. Vitamin A deficiency resulted in a significantly impaired in vivo incorporation of mannose in liver glycoprotein but had no effect on the in vitro transport of mannose via retinyl phosphate. Although DDT induced an increase synthesis of liver proteins in smooth endoplasmic reticulum and caused a diminution of the hepatic vitamin A content, it did not affect vitamin A-dependent protein mannosylation.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Vitamina A
/
Deficiência de Vitamina A
/
Glicoproteínas
/
DDT
/
Fígado
/
Manose
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article