Micropatterned coculture of hepatocytes on electrospun fibers as a potential in vitro model for predictive drug metabolism.

Liu, Yaowen; Wei, Jiaojun; Lu, Jinfu; Lei, Dongmei; Yan, Shili; Li, Xiaohong

Liu, Yaowen; Wei, Jiaojun; Lu, Jinfu; Lei, Dongmei; Yan, Shili; Li, Xiaohong.

Afiliação

Liu Y; Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China; College of Food Science, Sichuan Agricultural University, Yaan 625014, PR China.
Wei J; Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China.
Lu J; Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China.
Lei D; Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China.
Yan S; Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China.
Li X; Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China. Electronic address: xhli@swjtu.edu.cn.

Mater Sci Eng C Mater Biol Appl ; 63: 475-84, 2016 Jun.

Article em En | MEDLINE | ID: mdl-27040241

Assuntos

Hepatócitos/metabolismo; Preparações Farmacêuticas/metabolismo; Animais; Células Cultivadas; Técnicas de Cocultura; Citocromo P-450 CYP2C9/genética; Citocromo P-450 CYP2C9/metabolismo; Citocromo P-450 CYP3A/genética; Citocromo P-450 CYP3A/metabolismo; Células Endoteliais/citologia; Células Endoteliais/metabolismo; Fibroblastos/citologia; Fibroblastos/metabolismo; Hepatócitos/citologia; Masculino; Microscopia Confocal; Microscopia Eletrônica de Varredura; Midazolam/metabolismo; Ratos; Ratos Sprague-Dawley; Reação em Cadeia da Polimerase em Tempo Real; Tolbutamida/metabolismo; Varfarina/metabolismo

Palavras-chave

Drug metabolism; Drug-drug interaction; Hepatocyte coculture; Hepatocyte spheroid; Micropatterned fibrous mats

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Hepatócitos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Hepatócitos Idioma: En Ano de publicação: 2016 Tipo de documento: Article