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Biosensing made easy with PEG-targeted bi-specific antibodies.
Raftery, Lyndon J; Grewal, Yadveer S; Howard, Christopher B; Jones, Martina L; Shiddiky, Muhammad J A; Carrascosa, Laura G; Thurecht, Kristofer J; Mahler, Stephen M; Trau, Matt.
Afiliação
  • Raftery LJ; Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, QLD 4072, Australia.
  • Grewal YS; Centre for Personalised NanoMedicine, AIBN, University of Queensland, Brisbane, QLD 4072, Australia.
  • Howard CB; Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, QLD 4072, Australia and Centre for Advanced Imaging (CAI), University of Queensland, Brisbane, QLD 4072, Australia.
  • Jones ML; Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, QLD 4072, Australia.
  • Shiddiky MJ; Centre for Personalised NanoMedicine, AIBN, University of Queensland, Brisbane, QLD 4072, Australia.
  • Carrascosa LG; Centre for Personalised NanoMedicine, AIBN, University of Queensland, Brisbane, QLD 4072, Australia.
  • Thurecht KJ; Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, QLD 4072, Australia and Centre for Advanced Imaging (CAI), University of Queensland, Brisbane, QLD 4072, Australia and ARC Centre of Excellence in Convergent BioNano Science and Technology, Univers
  • Mahler SM; Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, QLD 4072, Australia and School of Chemical Engineering, University of Queensland, Brisbane, QLD 4072, Australia. s.mahler.eng.uq.edu.au.
  • Trau M; Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, QLD 4072, Australia and Centre for Personalised NanoMedicine, AIBN, University of Queensland, Brisbane, QLD 4072, Australia and School of Chemistry and Molecular Biosciences (SCMB), University of Q
Chem Commun (Camb) ; 52(33): 5730-3, 2016 Apr 28.
Article em En | MEDLINE | ID: mdl-27045479
ABSTRACT
Whilst recent advances in nanotechnology have yielded many new biosensing capabilities, innovative biological attachment and detection modalities remain relatively underdeveloped. Bi-specific antibodies (bsAbs)--which exhibit binding capability for two separate targets--offer an inherent advantage over conventional antibody reagents by significantly simplifying sensor surface preparation. Herein, we report the deployment of bsAbs for simultaneous attachment to a polymer-coated transducer and label-free, electrochemical (EC) detection of target antigens.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Técnicas Biossensoriais / Anticorpos Biespecíficos Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Técnicas Biossensoriais / Anticorpos Biespecíficos Idioma: En Ano de publicação: 2016 Tipo de documento: Article