Myocardial Ischemia Induces SDF-1α Release in Cardiac Surgery Patients.
J Cardiovasc Transl Res
; 9(3): 230-238, 2016 06.
Article
em En
| MEDLINE
| ID: mdl-27055858
ABSTRACT
In the present observational study, we measured serum levels of the chemokine stromal cell-derived factor-1α (SDF-1α) in 100 patients undergoing cardiac surgery with cardiopulmonary bypass at seven distinct time points including preoperative values, myocardial ischemia, reperfusion, and the postoperative course. Myocardial ischemia triggered a marked increase of SDF-1α serum levels whereas cardiac reperfusion had no significant influence. Perioperative SDF-1α serum levels were influenced by patients' characteristics (e.g., age, gender, aspirin intake). In an explorative analysis, we observed an inverse association between SDF-1α serum levels and the incidence of organ dysfunction. In conclusion, time of myocardial ischemia was identified as the key stimulus for a significant upregulation of SDF-1α, indicating its role as a marker of myocardial injury. The inverse association between SDF-1α levels and organ dysfunction association encourages further studies to evaluate its organoprotective properties in cardiac surgery patients.
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Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
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Traumatismo por Reperfusão Miocárdica
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Ponte de Artéria Coronária
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Implante de Prótese de Valva Cardíaca
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Quimiocina CXCL12
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Doenças das Valvas Cardíacas
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article