Hyaluronidase Embedded in Nanocarrier PEG Shell for Enhanced Tumor Penetration and Highly Efficient Antitumor Efficacy.

Zhou, Hao; Fan, Zhiyuan; Deng, Junjie; Lemons, Pelin K; Arhontoulis, Dimitrios C; Bowne, Wilbur B; Cheng, Hao

Zhou, Hao; Fan, Zhiyuan; Deng, Junjie; Lemons, Pelin K; Arhontoulis, Dimitrios C; Bowne, Wilbur B; Cheng, Hao.

Afiliação

Zhou H; Department of Materials Science and Engineering, and School of Biomedical Engineering, Science and Health Systems, Drexel University , Philadelphia, Pennsylvania 19104, United States.
Fan Z; Department of Surgery, Drexel University , Philadelphia, Pennsylvania 19102, United States.
Deng J; Department of Materials Science and Engineering, and School of Biomedical Engineering, Science and Health Systems, Drexel University , Philadelphia, Pennsylvania 19104, United States.
Lemons PK; Department of Surgery, Drexel University , Philadelphia, Pennsylvania 19102, United States.
Arhontoulis DC; Department of Materials Science and Engineering, and School of Biomedical Engineering, Science and Health Systems, Drexel University , Philadelphia, Pennsylvania 19104, United States.
Bowne WB; Department of Surgery, Drexel University , Philadelphia, Pennsylvania 19102, United States.
Cheng H; Department of Materials Science and Engineering, and School of Biomedical Engineering, Science and Health Systems, Drexel University , Philadelphia, Pennsylvania 19104, United States.

Nano Lett ; 16(5): 3268-77, 2016 05 11.

Article em En | MEDLINE | ID: mdl-27057591

Assuntos

Antineoplásicos/química; Portadores de Fármacos/química; Hialuronoglucosaminidase/química; Nanopartículas/química; Poliésteres/química; Polietilenoglicóis/química; Animais; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Apoptose/efeitos dos fármacos; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Relação Dose-Resposta a Droga; Doxorrubicina/química; Doxorrubicina/farmacologia; Doxorrubicina/uso terapêutico; Liberação Controlada de Fármacos; Matriz Extracelular/metabolismo; Feminino; Humanos; Isoenxertos; Neoplasias Mamárias Animais/tratamento farmacológico; Camundongos Endogâmicos BALB C; Tamanho da Partícula; Proteínas Recombinantes/química; Distribuição Tecidual

Palavras-chave

Extracellular matrix; appoptosis; drug release; heterogeneous; hyaluronan

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poliésteres / Polietilenoglicóis / Portadores de Fármacos / Nanopartículas / Hialuronoglucosaminidase / Antineoplásicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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