ROQUIN signalling pathways in innate and adaptive immunity.
Eur J Immunol
; 46(5): 1082-90, 2016 05.
Article
em En
| MEDLINE
| ID: mdl-27060455
ROQUIN is an RNA-binding protein that plays important roles in both the innate and adaptive immune systems. ROQUIN binds to several key immune-relevant messenger RNA (mRNA) targets through its ROQ domain modulating their stability and influencing macrophage function and the peripheral homeostasis of T cells and B cells. More recently, the E3 ubiquitin ligase activity of the ROQUIN RING domain has been shown to be crucial for T-cell-dependent B-cell responses against infection. Defective ROQUIN activity can culminate in a range of diseases, such as systemic autoimmunity, immunodeficiency, and inflammatory bowel disorder. Here, we provide a current overview of the immunomodulatory role of ROQUIN defined by its ribonucleoprotein-like structure, its repertoire of mRNA targets shared by related RNA-binding enzymes, and its involvement in a range of intracellular signalling pathways central to shaping immune responses.
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MEDLINE
Assunto principal:
Transdução de Sinais
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Proteínas de Ligação a RNA
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Ubiquitina-Proteína Ligases
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Imunomodulação
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Imunidade Adaptativa
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Imunidade Inata
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article