Aromatase inhibitors augment nociceptive behaviors in rats and enhance the excitability of sensory neurons.

Robarge, Jason D; Duarte, Djane B; Shariati, Behzad; Wang, Ruizhong; Flockhart, David A; Vasko, Michael R

Robarge, Jason D; Duarte, Djane B; Shariati, Behzad; Wang, Ruizhong; Flockhart, David A; Vasko, Michael R.

Afiliação

Robarge JD; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States; Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN, United States. Electronic address: jrobarge@iu.edu.
Duarte DB; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States; Laboratório de Farmacologia Molecular, Faculdade de Ciências da Saúde, Universidade de Brasília, Brazil. Electronic address: djane@unb.br.
Shariati B; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States. Electronic address: bshariat@umail.iu.edu.
Wang R; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States. Electronic address: rewang@iupui.edu.
Flockhart DA; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States; Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN, United States. Electronic address: dflockha@iupui.edu.
Vasko MR; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States. Electronic address: vaskom@iupui.edu.

Exp Neurol ; 281: 53-65, 2016 07.

Article em En | MEDLINE | ID: mdl-27072527

Assuntos

Inibidores da Aromatase/efeitos adversos; Hiperalgesia/induzido quimicamente; Nociceptividade/efeitos dos fármacos; Limiar da Dor/efeitos dos fármacos; Células Receptoras Sensoriais/efeitos dos fármacos; Trifosfato de Adenosina/farmacologia; Androstadienos/efeitos adversos; Androstadienos/farmacologia; Animais; Inibidores da Aromatase/farmacologia; Peptídeo Relacionado com Gene de Calcitonina/metabolismo; Células Cultivadas; Modelos Animais de Doenças; Feminino; Gânglios Espinais/citologia; Hipestesia/induzido quimicamente; Letrozol; Masculino; Potenciais da Membrana/efeitos dos fármacos; Nitrilas/efeitos adversos; Nitrilas/farmacologia; Ovariectomia; Medição da Dor; Ratos; Ratos Sprague-Dawley; Medula Espinal/citologia; Medula Espinal/efeitos dos fármacos; Medula Espinal/metabolismo; Triazóis/efeitos adversos; Triazóis/farmacologia

Palavras-chave

Aromatase inhibitors; Calcitonin gene-related peptide; Electrophysiology; Excitability; Exemestane; Hypersensitivity; Letrozole; Nociception; Pain; Sensory neuron

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Receptoras Sensoriais / Limiar da Dor / Inibidores da Aromatase / Nociceptividade / Hiperalgesia Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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