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Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population.
Shimada-Sugimoto, Mihoko; Otowa, Takeshi; Miyagawa, Taku; Khor, Seik-Soon; Omae, Yosuke; Toyo-Oka, Licht; Sugaya, Nagisa; Kawamura, Yoshiya; Umekage, Tadashi; Miyashita, Akinori; Kuwano, Ryozo; Kaiya, Hisanobu; Kasai, Kiyoto; Tanii, Hisashi; Okazaki, Yuji; Tokunaga, Katsushi; Sasaki, Tsukasa.
Afiliação
  • Shimada-Sugimoto M; Department of Human Genetics, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
  • Otowa T; Graduate School of Clinical Psychology, Teikyo Heisei University Major of Professional Clinical Psychology , Tokyo, Japan.
  • Miyagawa T; Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Khor SS; Department of Human Genetics, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
  • Omae Y; Department of Human Genetics, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
  • Toyo-Oka L; Department of Human Genetics, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
  • Sugaya N; Department of Epidemiology and Public Health, Graduate School of Medicine, Yokohama City University , Kanagawa, Japan.
  • Kawamura Y; Department of Psychiatry, Shonan Kamakura General Hospital , Kanagawa, Japan.
  • Umekage T; Division for Environment, Health and Safety, The University of Tokyo , Tokyo, Japan.
  • Miyashita A; Department of Molecular Genetics, Center for Bioresources, Brain Research Institute, Niigata University , Niigata, Japan.
  • Kuwano R; Department of Molecular Genetics, Center for Bioresources, Brain Research Institute, Niigata University , Niigata, Japan.
  • Kaiya H; Panic Disorder Research Center, Warakukai Med. Corp. , Tokyo, Japan.
  • Kasai K; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
  • Tanii H; Department of Psychiatry, Institute of Medical Life Science, Graduate School of Medicine, Mie University , Mie, Japan.
  • Okazaki Y; Tokyo Metropolitan Matsuzawa Hospital , Tokyo, Japan.
  • Tokunaga K; Department of Human Genetics, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
  • Sasaki T; Department of Physical and Health Education, Graduate School of Education, The University of Tokyo , Tokyo, Japan.
Hum Genome Var ; 3: 16001, 2016.
Article em En | MEDLINE | ID: mdl-27081567
ABSTRACT
We herein report an association between TMEM132D and panic disorder (PD) in a Japanese population, evaluating the effects of HLA-DRB1*1302, which we previously reported as a susceptibility genetic factor for PD. SNPs in TMEM132D showed significant associations with PD in subjects without HLA-DRB1*1302 (rs4759997; P=5.02×10(-6), odds ratio=1.50) but not in those with the HLA allele. TMEM132D might have a role in the development of PD in subjects without HLA-DRB1*1302.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article