Cox26 is a novel stoichiometric subunit of the yeast cytochrome c oxidase.
Biochim Biophys Acta
; 1863(7 Pt A): 1624-32, 2016 Jul.
Article
em En
| MEDLINE
| ID: mdl-27083394
ABSTRACT
The cytochrome c oxidase (COX) is the terminal enzyme of the respiratory chain. The complex accepts electrons from cytochrome c and passes them onto molecular oxygen. This process contributes to energy capture in the form of a membrane potential across the inner membrane. The enzyme complex assembles in a stepwise process from the three mitochondria-encoded core subunits Cox1, Cox2 and Cox3, which associate with nuclear-encoded subunits and cofactors. In the yeast Saccharomyces cerevisiae, the cytochrome c oxidase associates with the bc1-complex into supercomplexes, allowing efficient energy transduction. Here we report on Cox26 as a protein found in respiratory chain supercomplexes containing cytochrome c oxidase. Our analyses reveal Cox26 as a novel stoichiometric structural subunit of the cytochrome c oxidase. A loss of Cox26 affects cytochrome c oxidase activity and respirasome organization.
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Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
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Complexo IV da Cadeia de Transporte de Elétrons
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Proteínas de Saccharomyces cerevisiae
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Membranas Mitocondriais
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Mitocôndrias
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article