POSH Regulates CD4+ T Cell Differentiation and Survival.
J Immunol
; 196(10): 4003-13, 2016 05 15.
Article
em En
| MEDLINE
| ID: mdl-27084103
ABSTRACT
The scaffold molecule POSH is crucial for the regulation of proliferation and effector function in CD8(+) T cells. However, its role in CD4(+) T cells is not known. In this study, we found that disruption of the POSH scaffold complex established a transcriptional profile that strongly skewed differentiation toward Th2, led to decreased survival, and had no effect on cell cycle entry. This is in stark contrast to CD8(+) T cells in which POSH regulates cell cycle and does not affect survival. Disruption of POSH in CD4(+) T cells resulted in the loss of Tak1-dependent activation of JNK1/2 and Tak1-mediated survival. However, in CD8(+) T cells, POSH regulates only JNK1. Remarkably, each type of T cell had a unique composition of the POSH scaffold complex and distinct posttranslational modifications of POSH. These data indicate that the mechanism that regulates POSH function in CD4(+) T cells is different from CD8(+) T cells. All together, these data strongly suggest that POSH is essential for the integration of cell-type-specific signals that regulate the differentiation, survival, and function of T cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
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Sobrevivência Celular
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Linfócitos T CD8-Positivos
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Proteínas do Citoesqueleto
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Proteínas Adaptadoras de Transdução de Sinal
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Equilíbrio Th1-Th2
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article