Peripheral blood lymphocyte micronucleus frequencies in men from areas of Kerala, India, with high vs normal levels of natural background ionizing radiation.
Mutat Res Genet Toxicol Environ Mutagen
; 800-801: 40-5, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-27085474
ABSTRACT
We have measured the frequencies of micronuclei (MN) in adult male individuals living in areas of the Kerala coast, southwest India, with either high (HLNRA, >1.5mGy/year) or normal levels of natural ionizing radiation (NLNRA, ≤1.5mGy/year). Blood samples were obtained from 141 individuals, 94 from HLNRA and 47 from NLNRA, aged 18-72, and were subjected to the cytokinesis-block micronucleus (CBMN) assay. An average of 1835 binucleated (BN) cells per individual were scored. The overall frequency of MN (mean±SD) was 11.7±6.7 per 1000 BN cells. The frequencies of MN in the HLNRA (11.7±6.6) and NLNRA (11.6±6.7) were not statistically significantly different (P=0.59). However, a statistically significant (P<0.001) age-dependent increase in MN frequency was observed among individuals from both HLNRA and NLNRA. No natural background radiation dose-dependent increase in MN frequency was seen. MN frequency was not influenced by tobacco smoking or chewing but it was increased among individuals consuming alcohol. Chronic low-dose radiation in the Kerala coast did not have a significant effect on MN frequency among adult men.
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Base de dados:
MEDLINE
Assunto principal:
Radiação Ionizante
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Linfócitos
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Testes para Micronúcleos
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Núcleo Celular
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article