Fixed-pressure CPAP versus auto-adjusting CPAP: comparison of efficacy on blood pressure in obstructive sleep apnoea, a randomised clinical trial.
Thorax
; 71(8): 726-33, 2016 08.
Article
em En
| MEDLINE
| ID: mdl-27091542
ABSTRACT
BACKGROUND:
Millions of individuals with obstructive sleep apnoea (OSA) are treated by CPAP aimed at reducing blood pressure (BP) and thus cardiovascular risk. However, evidence is scarce concerning the impact of different CPAP modalities on BP evolution.METHODS:
This double-blind, randomised clinical trial of parallel groups of patients with OSA indicated for CPAP treatment compared the efficacy of fixed-pressure CPAP (FP-CPAP) with auto-adjusting CPAP (AutoCPAP) in reducing BP. The primary endpoint was the change in office systolic BP after 4â months. Secondary endpoints included 24â h BP measurements.RESULTS:
Patients (322) were randomised to FP-CPAP (n=161) or AutoCPAP (n=161). The mean apnoea+hypopnoea index (AHI) was 43/h (SD, 21); mean age was 57 (SD, 11), with 70% of males; mean body mass index was 31.3â kg/m(2) (SD, 6.6) and median device use was 5.1â h/night. In the intention-to-treat analysis, office systolic blood pressure decreased by 2.2â mmâ Hg (95% CI -5.8 to 1.4) and 0.4â mmâ Hg (-4.3 to 3.4) in the FP-CPAP and AutoCPAP group, respectively (group difference -1.3â mmâ Hg (95% CI -4.1 to 1.5); p=0.37, adjusted for baseline BP values). 24â h diastolic BP (DBP) decreased by 1.7â mmâ Hg (95% CI -3.9 to 0.5) and 0.5â mmâ Hg (95% CI -2.3 to 1.3) in the FP-CPAP and AutoCPAP group, respectively (group difference -1.4â mmâ Hg (95% CI -2.7 to -0.01); p=0.048, adjusted for baseline BP values).CONCLUSIONS:
The result was negative regarding the primary outcome of office BP, while FP-CPAP was more effective in reducing 24â h DBP (a secondary outcome). TRIAL REGISTRATION NUMBER NCT01090297.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pressão Sanguínea
/
Apneia Obstrutiva do Sono
/
Pressão Positiva Contínua nas Vias Aéreas
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article