Synthesis, characterization and fluorescent properties of water-soluble glycopolymer bearing curcumin pendant residues.
Biosci Biotechnol Biochem
; 80(8): 1451-8, 2016 Aug.
Article
em En
| MEDLINE
| ID: mdl-27098211
ABSTRACT
Curcumin is a potential natural anticancer drug with low oral bioavailability because of poor water solubility. The aqueous solubility of curcumin is enhanced by means of modification with the carbohydrate units. Polymerization of the curcumin-containing monomer with carbohydrate-containing monomer gives the water-soluble glycopolymer bearing curcumin pendant residues. The obtained copolymers (P1 and P2) having desirable water solubility were well-characterized by infrared spectroscopy (IR), nuclear magnetic resonance (NMR), gel permeation chromatography (GPC), UV-Vis absorption spectroscopy, and photoluminescence spectroscopy. The copolymer P2 with a molar ratio of 16 (curcumin/carbohydrate) calculated from the proton NMR results exhibits a similar anticancer activity compared to original curcumin, which may serve as a potential chemotherapeutic agent in the field of anticancer medicine.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Curcumina
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Lipase
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Metacrilatos
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Metilglucosídeos
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Antineoplásicos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article