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Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6.
Uras, Iris Z; Walter, Gina J; Scheicher, Ruth; Bellutti, Florian; Prchal-Murphy, Michaela; Tigan, Anca S; Valent, Peter; Heidel, Florian H; Kubicek, Stefan; Scholl, Claudia; Fröhling, Stefan; Sexl, Veronika.
Afiliação
  • Uras IZ; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria;
  • Walter GJ; Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany; German Cancer Consortium, Heidelberg, Germany;
  • Scheicher R; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria;
  • Bellutti F; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria;
  • Prchal-Murphy M; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria;
  • Tigan AS; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria;
  • Valent P; Division of Hematology and Hemostaseology, Department of Internal Medicine I, and Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria;
  • Heidel FH; Department of Hematology and Oncology, Center for Internal Medicine II, Jena University Hospital, Jena, Germany;
  • Kubicek S; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; and.
  • Scholl C; Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany; German Cancer Consortium, Heidelberg, Germany;
  • Fröhling S; Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany; German Cancer Consortium, Heidelberg, Germany; Section for Personalized Oncology, Heidelberg University Hospital, Heidelberg, Germany.
  • Sexl V; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria;
Blood ; 127(23): 2890-902, 2016 06 09.
Article em En | MEDLINE | ID: mdl-27099147
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Piridinas / Leucemia Mieloide Aguda / Proteínas Proto-Oncogênicas / Proteínas Serina-Treonina Quinases / Quinase 6 Dependente de Ciclina / Tirosina Quinase 3 Semelhante a fms Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Piridinas / Leucemia Mieloide Aguda / Proteínas Proto-Oncogênicas / Proteínas Serina-Treonina Quinases / Quinase 6 Dependente de Ciclina / Tirosina Quinase 3 Semelhante a fms Idioma: En Ano de publicação: 2016 Tipo de documento: Article