RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.
Science
; 352(6284): 453-9, 2016 Apr 22.
Article
em En
| MEDLINE
| ID: mdl-27102483
ABSTRACT
Progression through the stages of lymphocyte development requires coordination of the cell cycle. Such coordination ensures genomic integrity while cells somatically rearrange their antigen receptor genes [in a process called variable-diversity-joining (VDJ) recombination] and, upon successful rearrangement, expands the pools of progenitor lymphocytes. Here we show that in developing B lymphocytes, the RNA-binding proteins (RBPs) ZFP36L1 and ZFP36L2 are critical for maintaining quiescence before precursor B cell receptor (pre-BCR) expression and for reestablishing quiescence after pre-BCR-induced expansion. These RBPs suppress an evolutionarily conserved posttranscriptional regulon consisting of messenger RNAs whose protein products cooperatively promote transition into the S phase of the cell cycle. This mechanism promotes VDJ recombination and effective selection of cells expressing immunoglobulin-µ at the pre-BCR checkpoint.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Nucleares
/
Linfócitos B
/
Fase S
/
Proteínas de Ligação a RNA
/
Tristetraprolina
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article