EBNA1 antigen-specific CD8+ T cells in cerebrospinal fluid of patients with multiple sclerosis.
J Neuroimmunol
; 294: 14-7, 2016 05 15.
Article
em En
| MEDLINE
| ID: mdl-27138093
ABSTRACT
Epidemiological data suggests that Epstein-Barr virus may be involved in the pathogenesis of Multiple Sclerosis (MS). We aimed to determine the frequency of CD8+ T cells specific for one EBNA1-derived epitope (HPVGEADYFEY) in cerebrospinal fluid (CSF) and blood of patients with MS and other inflammatory neurological diseases (OIND). The frequency of specific CD8+ T cells was assessed by HLA-class-I-binding pentamers restricted to HLA-B35. The frequency of HPVGEADYFEY-specific CD8+ T cells did neither differ significantly in blood nor CSF in MS compared to OIND, but was consistently higher in CSF compared to blood regardless of diagnosis.
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MEDLINE
Assunto principal:
Linfócitos T CD8-Positivos
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Antígenos Nucleares do Vírus Epstein-Barr
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Infecções por Vírus Epstein-Barr
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Esclerose Múltipla
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article