Pre-critical MRI findings of an Alzheimer's disease patient with pathologically proven cerebral amyloid angiopathy related lobar hemorrhage.
Rinsho Shinkeigaku
; 56(5): 338-43, 2016 05 31.
Article
em Ja
| MEDLINE
| ID: mdl-27151228
ABSTRACT
An 85-year-old woman with untreated hypertension was admitted with a disturbance of consciousness. On admission, brain CT revealed a lobar intracerebral hemorrhage with a midline shift. An intracranial hematoma was evacuated via a life-saving craniotomy. Definite pathological findings of amyloid-ß deposition in the excised hematoma (strong in anti-amyloid ß40 immunostain, but weak in anti- amyloid ß42) indicated cerebral amyloid angiopathy (CAA). She had been diagnosed with Alzheimer's disease at a regional memory clinic one month before symptom onset based on MRI findings of medial temporal lobe atrophy as well as CAA-related features of multiple strictly lobar cerebral microbleeds in the occipital lobe, cortical superficial siderosis and >20 enlarged perivascular spaces in the centrum semiovale. This experience suggests that comprehensive interpretation of such CAA-related findings on MRI might help to improve the management of cardiovascular risk factors for Alzheimer's disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
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Hemorragia Cerebral
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Angiopatia Amiloide Cerebral
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Doença de Alzheimer
Idioma:
Ja
Ano de publicação:
2016
Tipo de documento:
Article