Uterine serous carcinoma: a historic evaluation of therapy.
Eur J Gynaecol Oncol
; 37(2): 211-5, 2016.
Article
em En
| MEDLINE
| ID: mdl-27172747
ABSTRACT
UNLABELLED Summary OBJECTIVE:
Uterine serous carcinoma (USC) is an aggressive, histological subtype of endometrial cancer with a poor prognosis. This study evaluates the additional effect of staging surgery above total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH+BSO) on the use of adjuvant therapy and subsequent survival outcomes in clinical early-stage USC patients. MATERIALS ANDMETHODS:
This retrospective cohort study includes 75 women treated for clinical early-stage USC.RESULTS:
In 33 (44%) clinical early-stage patients surgical staging was performed and 15 patients (45%) proved to have lymphatic or abdominal metastasis. Use of adjuvant therapy was similar in patients, both staged with no metastasis (n = 18) and patients who underwent TAH and BSO only (n = 42, p = 0.17). No significant survival difference was found between surgically staged and TAH+BSO patients.CONCLUSIONS:
Surgical staging proved to be important to determine stage of disease and hence prognosis. Surgical staging did not lead to selective avoidance of adjuvant therapy in patients with no metastasis.
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Base de dados:
MEDLINE
Assunto principal:
Ovariectomia
/
Neoplasias do Endométrio
/
Quimioterapia Adjuvante
/
Neoplasias Císticas, Mucinosas e Serosas
/
Radioterapia Adjuvante
/
Salpingectomia
/
Quimiorradioterapia Adjuvante
/
Histerectomia
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article