Pharmacokinetics, biodistribution and excretion studies of neotuberostemonine, a major bioactive alkaloid of Stemona tuberosa.

Wu, Yan; Ou, Liting; Han, Dong; Tong, Yongbin; Zhang, Mian; Xu, Xianghong; Zhang, Chaofeng

Wu, Yan; Ou, Liting; Han, Dong; Tong, Yongbin; Zhang, Mian; Xu, Xianghong; Zhang, Chaofeng.

Afiliação

Wu Y; State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy, China Pharmaceutical University, 639# Longmian Road, Nanjing 211198, PR China.
Ou L; State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy, China Pharmaceutical University, 639# Longmian Road, Nanjing 211198, PR China.
Han D; State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy, China Pharmaceutical University, 639# Longmian Road, Nanjing 211198, PR China.
Tong Y; State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy, China Pharmaceutical University, 639# Longmian Road, Nanjing 211198, PR China.
Zhang M; State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy, China Pharmaceutical University, 639# Longmian Road, Nanjing 211198, PR China. Electronic address: mianzhang@126.com.
Xu X; State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy, China Pharmaceutical University, 639# Longmian Road, Nanjing 211198, PR China.
Zhang C; State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy, China Pharmaceutical University, 639# Longmian Road, Nanjing 211198, PR China. Electronic address: njchaofeng@126.com.

Fitoterapia ; 112: 22-9, 2016 Jul.

Article em En | MEDLINE | ID: mdl-27179627

Assuntos

Alcaloides/farmacocinética; Lactonas/farmacocinética; Stemonaceae/química; Animais; Bile/química; Cromatografia Líquida de Alta Pressão; Medicamentos de Ervas Chinesas/farmacocinética; Fezes/química; Intestinos/química; Fígado/química; Masculino; Ratos; Ratos Sprague-Dawley; Estômago/química; Espectrometria de Massas em Tandem; Distribuição Tecidual; Urina/química

Palavras-chave

Excretion; Neotuberostemonine; Pharmacokinetics; Stemona tuberosa; Tissue distribution; UPLC-MS/MS

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Stemonaceae / Alcaloides / Lactonas Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Stemonaceae / Alcaloides / Lactonas Idioma: En Ano de publicação: 2016 Tipo de documento: Article