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A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion.
Raimondi, Claudio; Calleja, Veronique; Ferro, Riccardo; Fantin, Alessandro; Riley, Andrew M; Potter, Barry V L; Brennan, Caroline H; Maffucci, Tania; Larijani, Banafshé; Falasca, Marco.
Afiliação
  • Raimondi C; Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, Inositide Signalling Group, London E1 2AT, UK.
  • Calleja V; Cell Biophysics Laboratory, Cancer Research UK, Lincoln's Inn Fields Laboratories, London Research Institute, London WC2A 3LY, UK.
  • Ferro R; Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, Inositide Signalling Group, London E1 2AT, UK.
  • Fantin A; UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.
  • Riley AM; Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK.
  • Potter BV; Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK.
  • Brennan CH; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT.
  • Maffucci T; Queen Mary University of London, School of Biological and Chemical Sciences, London E1 4NS, UK.
  • Larijani B; Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, Inositide Signalling Group, London E1 2AT, UK.
  • Falasca M; Cell Biophysics Laboratory, Cancer Research UK, Lincoln's Inn Fields Laboratories, London Research Institute, London WC2A 3LY, UK.
Sci Rep ; 6: 26142, 2016 05 20.
Article em En | MEDLINE | ID: mdl-27199173
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Inibidores Enzimáticos / Fosfolipase C gama / Fosfatos de Inositol / Antineoplásicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Inibidores Enzimáticos / Fosfolipase C gama / Fosfatos de Inositol / Antineoplásicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article