Can Kidney Transplantation Improve Arterial Stiffness in End-Stage Renal Patients?
Transplant Proc
; 48(3): 884-6, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-27234758
ABSTRACT
BACKGROUND:
Arterial stiffness is associated with cardiovascular disease in end-stage renal disease (ESRD) and after kidney transplantation. We examined how kidney transplantation influences brachial-ankle pulse-wave velocity (baPWV) in ESRD patients.METHODS:
The prospective observational study enrolled 67 patients who underwent successful kidney transplantation. Serial baPWV and biochemical parameters were measured before surgery and 6 months, 1 year, and 2 years after transplantation.RESULTS:
baPWV prior to kidney transplantation and 6 months, 1 year, and 2 years after transplantation was 1533 ± 261 cm/s, 1417 ± 254 cm/s, 1414 ± 285 cm/s, and 1384 ± 233 cm/s, respectively. baPWV and biochemical parameters including alkaline phosphatase, intact parathyroid hormone, and 1,25 hydroxyvitamin D improved significantly at 6 months (P < .05), but there were no changes between 6 months and 2 years after transplantation. The majority of patients (73%) improved, whereas the remainder showed progression of baPWV after transplantation. Sixty-three percent of all kidney transplantation patients displayed higher baPWV than the healthy control subjects at 6 months after transplant.CONCLUSIONS:
In the majority of patients, baPWV improved soon after kidney transplantation but overall remained higher than in the generally healthy population.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Artéria Braquial
/
Transplante de Rim
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Recuperação de Função Fisiológica
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Rigidez Vascular
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Falência Renal Crônica
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article