Association Between the Polyomaviruses Titers and Decoy Cell Positivity Rates After Renal Transplantation.
Transplant Proc
; 48(3): 921-3, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-27234768
ABSTRACT
BACKGROUND:
Urinary decoy cells develop after renal transplantation and their appearance is attributable primarily to the proliferation of polyomavirus types BK and JC. We measured the levels of these 2 viruses that cause decoy cells to appear in the urine. PATIENTS ANDMETHODS:
BK and JC virus levels were quantified in 1182 urine samples from 335 renal transplant patients using a multiplex Taqman real-time polymerase chain reaction assay. Forty-four samples were excluded from analyses because both viruses were present at ≥10(4) copies/mL. We analyzed the relationship between viral load and the presence of urinary decoy cells.RESULTS:
Decoy cells were observed in 237 of 1138 urine samples (21%) and the BK and JC viruses were positive in 205 (18%) and 455 (40%) samples, respectively. Decoy cells were observed in 0%, 21%, 67%, 87%, 100%, and 96% of urine samples when the BK viral load was <10(4), 10(4)-10(5), 10(5)-10(6), 10(6)-10(7), 10(7)-10(8), and ≥10(8) copies/mL, respectively; and in 1%, 13%, 41%, 59%, 87%, and 97% of urine samples when the JC viral load was <10(4), 10(4)-10(5), 10(5)-10(6), 10(6)-10(7), 10(7)-10(8), and ≥10(8) copies/mL, respectively.CONCLUSIONS:
BK virus more frequently triggered the appearance of decoy cells than did JC virus at equivalent viral titers.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Transplante de Rim
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Vírus BK
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Vírus JC
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Infecções por Polyomavirus
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Falência Renal Crônica
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article