Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice.
Cell Host Microbe
; 19(6): 837-48, 2016 Jun 08.
Article
em En
| MEDLINE
| ID: mdl-27237364
ABSTRACT
Trypanosoma brucei is an extracellular parasite that causes sleeping sickness. In mammalian hosts, trypanosomes are thought to exist in two major niches early in infection, they populate the blood; later, they breach the blood-brain barrier. Working with a well-established mouse model, we discovered that adipose tissue constitutes a third major reservoir for T. brucei. Parasites from adipose tissue, here termed adipose tissue forms (ATFs), can replicate and were capable of infecting a naive animal. ATFs were transcriptionally distinct from bloodstream forms, and the genes upregulated included putative fatty acid ß-oxidation enzymes. Consistent with this, ATFs were able to utilize exogenous myristate and form ß-oxidation intermediates, suggesting that ATF parasites can use fatty acids as an external carbon source. These findings identify the adipose tissue as a niche for T. brucei during its mammalian life cycle and could potentially explain the weight loss associated with sleeping sickness.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trypanosoma brucei brucei
/
Tripanossomíase Africana
/
Tecido Adiposo
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article