Intragenic Locus in Human PIWIL2 Gene Shares Promoter and Enhancer Functions.
PLoS One
; 11(6): e0156454, 2016.
Article
em En
| MEDLINE
| ID: mdl-27248499
ABSTRACT
Recently, more evidence supporting common nature of promoters and enhancers has been accumulated. In this work, we present data on chromatin modifications and non-polyadenylated transcription characteristic for enhancers as well as results of in vitro luciferase reporter assays suggesting that PIWIL2 alternative promoter in exon 7 also functions as an enhancer for gene PHYHIP located 60Kb upstream. This finding of an intragenic enhancer serving as a promoter for a shorter protein isoform implies broader impact on understanding enhancer-promoter networks in regulation of gene expression.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Elementos Facilitadores Genéticos
/
Regiões Promotoras Genéticas
/
Proteínas Argonautas
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article