Venetoclax: Bcl-2 inhibition for the treatment of chronic lymphocytic leukemia.
Drugs Today (Barc)
; 52(4): 249-60, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-27252989
ABSTRACT
Venetoclax (ABT-199) is a small-molecule selective oral inhibitor of the antiapoptotic protein Bcl-2 that promotes programmed cell death of chronic lymphocytic leukemia (CLL) cells regulating the release of proapoptotic factors, such as Smac/Diablo, apoptosis-inducing factor (AIF) and cytochrome c. In April 2016, the U.S. Food and Drug Administration (FDA) granted accelerated approval to venetoclax for patients diagnosed with CLL with 17p deletion, as detected by an FDA-approved test, who have received at least one prior therapy. This review will focus on the mechanism of action, preclinical studies and clinical development of venetoclax both as a monotherapy and in combination with other drugs for CLL in the current milieu of therapy dominated by novel tyrosine kinase inhibitors such as ibrutinib and idelalisib.
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Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
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Leucemia Linfocítica Crônica de Células B
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Compostos Bicíclicos Heterocíclicos com Pontes
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Proteínas Proto-Oncogênicas c-bcl-2
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Antineoplásicos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article