ABCB1 1199G>A polymorphism (rs2229109) affects the transport of imatinib, nilotinib and dasatinib.

Dessilly, Géraldine; Elens, Laure; Panin, Nadtha; Karmani, Linda; Demoulin, Jean-Baptiste; Haufroid, Vincent

Dessilly, Géraldine; Elens, Laure; Panin, Nadtha; Karmani, Linda; Demoulin, Jean-Baptiste; Haufroid, Vincent.

Afiliação

Dessilly G; Louvain Centre for Toxicology & Applied Pharmacology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium.
Elens L; Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Panin N; Louvain Centre for Toxicology & Applied Pharmacology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium.
Karmani L; Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Demoulin JB; De Duve Institute, Université catholique de Louvain, Brussels, Belgium.
Haufroid V; Louvain Centre for Toxicology & Applied Pharmacology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium.

Pharmacogenomics ; 17(8): 883-90, 2016 06.

Article em En | MEDLINE | ID: mdl-27268766

Assuntos

Antineoplásicos/farmacocinética; Dasatinibe/farmacocinética; Mesilato de Imatinib/farmacocinética; Polimorfismo de Nucleotídeo Único; Pirimidinas/farmacocinética; Subfamília B de Transportador de Cassetes de Ligação de ATP/genética; Transporte Biológico; Células HEK293; Humanos; Células K562

Palavras-chave

ABCB1; ABCB1 1199G>A; HEK293; K562; SNP; dasatinib; imatinib; nilotinib

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Polimorfismo de Nucleotídeo Único / Mesilato de Imatinib / Dasatinibe / Antineoplásicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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