Blood neutrophil-lymphocyte ratio predicts survival after hepatectomy for hepatocellular carcinoma: A propensity score-based analysis.
World J Gastroenterol
; 22(21): 5088-95, 2016 Jun 07.
Article
em En
| MEDLINE
| ID: mdl-27275101
ABSTRACT
AIM:
To investigate whether an elevated preoperative neutrophil-to-lymphocyte ratio (NLR) can predict poor survival in patients with hepatocellular carcinoma (HCC).METHODS:
We retrospectively reviewed 526 patients with HCC who underwent surgery between 2004 and 2011.RESULTS:
Preoperative NLR ≥ 2.81 was an independent predictor of poor disease-free survival (DFS, P < 0.001) and overall survival (OS, P = 0.044). Compared with patients who showed a preoperative NLR < 2.81 and postoperative increase, patients who showed preoperative NLR ≥ 2.81 and postoperative decrease had worse survival (DFS, P < 0.001; OS, P < 0.001). Among patients with preoperative NLR ≥ 2.81, survival was significantly higher among those showing a postoperative decrease in NLR than among those showing an increase (DFS, P < 0.001; OS, P < 0.001). When elevated, alpha-fetoprotein (AFP) provided no prognostic information, and so preoperative NLR ≥ 2.81 may be a good complementary indicator of poor OS whenever AFP levels are low or high.CONCLUSION:
Preoperative NLR ≥ 2.81 may be an indicator of poor DFS and OS in patients with HCC undergoing surgery. Preoperative NLR ≥ 2.81 may be a good complementary indicator of poor OS when elevated AFP levels provide no prognostic information.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos
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Carcinoma Hepatocelular
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Hepatectomia
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Neoplasias Hepáticas
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Neutrófilos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article