Ras signaling through RASSF proteins.
Semin Cell Dev Biol
; 58: 86-95, 2016 10.
Article
em En
| MEDLINE
| ID: mdl-27288568
ABSTRACT
There are six core RASSF family proteins that contain conserved Ras Association domains and may serve as Ras effectors. They lack intrinsic enzymatic activity and appear to function as scaffolding and localization molecules. While initially being associated with pro-apoptotic signaling pathways such as Bax and Hippo, it is now clear that they can also connect Ras to a surprisingly broad range of signaling pathways that control senescence, inflammation, autophagy, DNA repair, ubiquitination and protein acetylation. Moreover, they may be able to impact the activation status of pro-mitogenic Ras effector pathways, such as the Raf pathway. The frequent epigenetic inactivation of RASSF genes in human tumors disconnects Ras from pro-death signaling systems, enhancing Ras driven transformation and metastasis. The best characterized members are RASSF1A and RASSF5 (NORE1A).
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Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Proteínas ras
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Proteínas Supressoras de Tumor
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article