A switch in G protein coupling for type 1 corticotropin-releasing factor receptors promotes excitability in epileptic brains.

Narla, Chakravarthi; Scidmore, Tanner; Jeong, Jaymin; Everest, Michelle; Chidiac, Peter; Poulter, Michael O

Narla, Chakravarthi; Scidmore, Tanner; Jeong, Jaymin; Everest, Michelle; Chidiac, Peter; Poulter, Michael O.

Afiliação

Narla C; Molecular Medicine Research Group, Robarts Research Institute, Schulich School of Medicine, University of Western Ontario, London, Ontario N6A 5K8, Canada. Department of Physiology and Pharmacology, Schulich School of Medicine, University of Western Ontario, London, Ontario N6A 3K7, Canada.
Scidmore T; Molecular Medicine Research Group, Robarts Research Institute, Schulich School of Medicine, University of Western Ontario, London, Ontario N6A 5K8, Canada. Department of Physiology and Pharmacology, Schulich School of Medicine, University of Western Ontario, London, Ontario N6A 3K7, Canada.
Jeong J; Molecular Medicine Research Group, Robarts Research Institute, Schulich School of Medicine, University of Western Ontario, London, Ontario N6A 5K8, Canada. Graduate Program in Neuroscience, Schulich School of Medicine, University of Western Ontario, London, Ontario N6A 5K8, Canada.
Everest M; Molecular Medicine Research Group, Robarts Research Institute, Schulich School of Medicine, University of Western Ontario, London, Ontario N6A 5K8, Canada.
Chidiac P; Department of Physiology and Pharmacology, Schulich School of Medicine, University of Western Ontario, London, Ontario N6A 3K7, Canada. Department of Biology, Schulich School of Medicine, University of Western Ontario, London, Ontario N6A 3K7, Canada.
Poulter MO; Molecular Medicine Research Group, Robarts Research Institute, Schulich School of Medicine, University of Western Ontario, London, Ontario N6A 5K8, Canada. Department of Physiology and Pharmacology, Schulich School of Medicine, University of Western Ontario, London, Ontario N6A 3K7, Canada. Graduate

Sci Signal ; 9(432): ra60, 2016 06 14.

Article em En | MEDLINE | ID: mdl-27303056

Assuntos

Epilepsia/metabolismo; Córtex Piriforme/metabolismo; Receptores de Hormônio Liberador da Corticotropina/metabolismo; Transdução de Sinais; Animais; Hormônio Liberador da Corticotropina/genética; Hormônio Liberador da Corticotropina/metabolismo; Epilepsia/genética; Subunidades alfa de Proteínas de Ligação ao GTP/genética; Subunidades alfa de Proteínas de Ligação ao GTP/metabolismo; Masculino; Camundongos; Camundongos Knockout; Córtex Piriforme/patologia; Córtex Piriforme/fisiopatologia; Proteínas RGS/genética; Proteínas RGS/metabolismo; Ratos; Ratos Sprague-Dawley; Receptores de Hormônio Liberador da Corticotropina/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Receptores de Hormônio Liberador da Corticotropina / Epilepsia / Córtex Piriforme Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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