miR-17-92 explains MYC oncogene addiction.

Li, Yulin; Casey, Stephanie C; Choi, Peter S; Felsher, Dean W

Li, Yulin; Casey, Stephanie C; Choi, Peter S; Felsher, Dean W.

Afiliação

Li Y; Division of Oncology; Departments of Medicine and Pathology; Stanford University ; Stanford, CA USA.
Casey SC; Division of Oncology; Departments of Medicine and Pathology; Stanford University ; Stanford, CA USA.
Choi PS; Division of Oncology; Departments of Medicine and Pathology; Stanford University ; Stanford, CA USA.
Felsher DW; Division of Oncology; Departments of Medicine and Pathology; Stanford University ; Stanford, CA USA.

Mol Cell Oncol ; 1(4): e970092, 2014.

Article em En | MEDLINE | ID: mdl-27308380

ABSTRACT

ABSTRACT

MYC regulates tumorigenesis by coordinating the expression of thousands of genes. We found that MYC appears to regulate the decisions between cell survival versus death and self-renewal versus senescence through the microRNA miR-17-92 cluster. Addiction to the MYC oncogene may therefore in fact be an addiction to miR-17-92.

Palavras-chave

MYC; lymphoma; microRNA miR-17-92; oncogene addiction

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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