Differential sensitivity of metabolically competent and non-competent HepaRG cells to apoptosis induced by diclofenac combined or not with TNF-&#945;.

Al-Attrache, Houssein; Sharanek, Ahmad; Burban, Audrey; Burbank, Matthew; Gicquel, Thomas; Abdel-Razzak, Ziad; Guguen-Guillouzo, Christiane; Morel, Isabelle; Guillouzo, André

Differential sensitivity of metabolically competent and non-competent HepaRG cells to apoptosis induced by diclofenac combined or not with TNF-α.

Al-Attrache, Houssein; Sharanek, Ahmad; Burban, Audrey; Burbank, Matthew; Gicquel, Thomas; Abdel-Razzak, Ziad; Guguen-Guillouzo, Christiane; Morel, Isabelle; Guillouzo, André.

Afiliação

Al-Attrache H; Inserm U991, Faculty of Pharmacy, Rennes, France; Rennes 1 University, Rennes, France; Laboratory of Applied Biotechnology: biomolecules, biotherapy and bioprocesses (LBA3B), AZM Center-Tripoli and EDST-PRASE-Beirut, Rafic Hariri Campus-Lebanese University, Lebanon.
Sharanek A; Inserm U991, Faculty of Pharmacy, Rennes, France; Rennes 1 University, Rennes, France.
Burban A; Inserm U991, Faculty of Pharmacy, Rennes, France; Rennes 1 University, Rennes, France.
Burbank M; Inserm U991, Faculty of Pharmacy, Rennes, France; Rennes 1 University, Rennes, France.
Gicquel T; Inserm U991, Faculty of Pharmacy, Rennes, France; Rennes 1 University, Rennes, France; Laboratory Emergency and Intensive Care, Hospital Pontchaillou, Rennes, France.
Abdel-Razzak Z; Laboratory of Applied Biotechnology: biomolecules, biotherapy and bioprocesses (LBA3B), AZM Center-Tripoli and EDST-PRASE-Beirut, Rafic Hariri Campus-Lebanese University, Lebanon.
Guguen-Guillouzo C; Inserm U991, Faculty of Pharmacy, Rennes, France; Rennes 1 University, Rennes, France.
Morel I; Inserm U991, Faculty of Pharmacy, Rennes, France; Rennes 1 University, Rennes, France; Laboratory Emergency and Intensive Care, Hospital Pontchaillou, Rennes, France.
Guillouzo A; Inserm U991, Faculty of Pharmacy, Rennes, France; Rennes 1 University, Rennes, France. Electronic address: Andre.Guillouzo@univ-rennes1.fr.

Toxicol Lett ; 258: 71-86, 2016 Sep 06.

Article em En | MEDLINE | ID: mdl-27313093

Assuntos

Anti-Inflamatórios não Esteroides/farmacologia; Apoptose/efeitos dos fármacos; Diclofenaco/farmacologia; Resistência a Medicamentos; Hepatócitos/efeitos dos fármacos; Fator de Necrose Tumoral alfa/metabolismo; Receptor fas/agonistas; Anti-Inflamatórios não Esteroides/agonistas; Anti-Inflamatórios não Esteroides/metabolismo; Biotransformação/efeitos dos fármacos; Diferenciação Celular; Linhagem Celular; Células Cultivadas; Diclofenaco/agonistas; Diclofenaco/metabolismo; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Inibidores Enzimáticos; Glutationa Transferase/antagonistas & inibidores; Glutationa Transferase/metabolismo; Células Hep G2; Hepatócitos/citologia; Hepatócitos/metabolismo; Humanos; Concentração Inibidora 50; Cinética; Microscopia de Contraste de Fase; Estresse Oxidativo/efeitos dos fármacos; Receptor fas/metabolismo

Palavras-chave

Caspases; Cholestasis; Differentiation status; Drug metabolism; Endoplasmic reticulum stress; Glutathione transferases; HepG2 cells; Primary human hepatocytes; Reactive oxygen species; Tumor necrosis factor α

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistência a Medicamentos / Anti-Inflamatórios não Esteroides / Diclofenaco / Fator de Necrose Tumoral alfa / Apoptose / Receptor fas / Hepatócitos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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