Multiple roles for the hippo effector yap in gut regeneration and cancer initiation.
Mol Cell Oncol
; 3(3): e1143992, 2016 May.
Article
em En
| MEDLINE
| ID: mdl-27314094
ABSTRACT
The Hippo signaling effector Yes-associated protein (Yap) is known for its potent control of tissue growth. Our recent work now shows that Yap promotes regeneration in the intestine by reprogramming intestinal stem cells and blocking their terminal differentiation. Similarly, in tumor-initiating cells Yap regenerative signaling synergizes with Wnt activation to drive adenoma formation.
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MEDLINE
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En
Ano de publicação:
2016
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Article