Novel class of Bi(iii) hydroxamato complexes: synthesis, urease inhibitory activity and activity against H. pylori.
Dalton Trans
; 45(27): 11008-14, 2016 Jul 05.
Article
em En
| MEDLINE
| ID: mdl-27314129
ABSTRACT
Reaction of Bi(NO3)3 with benzohydroxamic acid (Bha) and salicylhydroxamic acid (Sha) gives the novel Bi(iii) complexes [Bi2(Bha-1H)2(µ-Bha-1H)2(η(2)-NO3)2] () and [Bi6(CH3OH)2(η(1)-NO3)2(η(2)-NO3)(OH2)2(Sha-1H)12](NO3)2 (). X-ray crystal structure of reveals two hydroxamato coordination modes; bidentate bridging (O, O') and bidentate non-bridging (O, O') and of reveals one coordination mode; bidentate bridging (O, O'). , specifically designed to and demonstrated to inhibit the activity of urease, exhibits excellent antibacterial activity against three strains of Helicobacter pylori with MIC ≥ 16 µg mL(-1).
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Base de dados:
MEDLINE
Assunto principal:
Urease
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Bismuto
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Helicobacter pylori
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Inibidores Enzimáticos
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Complexos de Coordenação
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Antibacterianos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article