Four new minor brominated indole related alkaloids with antibacterial activities from Laurencia similis.
Bioorg Med Chem Lett
; 26(15): 3590-3, 2016 08 01.
Article
em En
| MEDLINE
| ID: mdl-27318539
ABSTRACT
Four new minor brominated indole related alkaloids (one indoles, 1, one 1,3-dihydro-indole-2-one, 2, one carbazole, 3, and one 2-carbonylamino-benzoate, 4) were isolated and identified from Laurencia similis by extensive chromatographic and spectrometric methods. Among them, 1 and 2 were the first example of naturally occurring indole with 3-benzyl group and 1,3-dihydro-indole-2-one with 2-isopropylidene group, respectively, whereas 3 and 4 were the first carbazole alkaloids and 2-carbonylamino-benzoate, respectively, isolated from the genus Laurencia. Moreover, 1 showed the most potent antibacterial activity against seven bacterial strains with MIC values ranging from 2 to 8µg/mL.
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Base de dados:
MEDLINE
Assunto principal:
Bactérias
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Laurencia
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Alcaloides
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Indóis
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Antibacterianos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article