Enantioselective total synthesis of (+)-Lingzhiol via tandem semipinacol rearrangement/Friedel-Crafts type cyclization.
Chem Commun (Camb)
; 52(55): 8561-4, 2016 Jun 30.
Article
em En
| MEDLINE
| ID: mdl-27321202
ABSTRACT
Enantioselective total synthesis of (+)-Lingzhiol has been achieved. It is the first example of in tandem semipinacol rearrangement reactions, the migrated aryl group further reacting with the carbonyl oxonium electrophile to furnish a polycyclic skeleton. Our synthesis involves 13 steps and proceeds in 6% overall yield.
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MEDLINE
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En
Ano de publicação:
2016
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Article