Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.
Nat Commun
; 7: 12021, 2016 06 21.
Article
em En
| MEDLINE
| ID: mdl-27323847
ABSTRACT
Regulatory T cells (Tregs) are essential to suppress unwanted immunity or inflammation. After islet allo-transplant Tregs must migrate from blood to allograft, then via afferent lymphatics to draining LN to protect allografts. Here we show that Tregs but not non-Treg T cells use lymphotoxin (LT) during migration from allograft to draining LN, and that LT deficiency or blockade prevents normal migration and allograft protection. Treg LTαß rapidly modulates cytoskeletal and membrane structure of lymphatic endothelial cells; dependent on VCAM-1 and non-canonical NFκB signalling via LTßR. These results demonstrate a form of T-cell migration used only by Treg in tissues that serves an important role in their suppressive function and is a unique therapeutic focus for modulating suppression.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transplante das Ilhotas Pancreáticas
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Linfócitos T Reguladores
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Diabetes Mellitus Experimental
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Heterotrímero de Linfotoxina alfa1 e beta2
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Receptor beta de Linfotoxina
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Migração Transendotelial e Transepitelial
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Rejeição de Enxerto
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article