Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-ß signalling.
Nat Commun
; 7: 12047, 2016 06 22.
Article
em En
| MEDLINE
| ID: mdl-27329220
ABSTRACT
Polycomb repressive complex 2 (PRC2) controls maintenance and lineage determination of stem cells by suppressing genes that regulate cellular differentiation and tissue development. However, the role of PRC2 in lineage-committed somatic cells is mostly unknown. Here we show that Eed deficiency in chondrocytes causes severe kyphosis and a growth defect with decreased chondrocyte proliferation, accelerated hypertrophic differentiation and cell death with reduced Hif1a expression. Eed deficiency also causes induction of multiple signalling pathways in chondrocytes. Wnt signalling overactivation is responsible for the accelerated hypertrophic differentiation and kyphosis, whereas the overactivation of TGF-ß signalling is responsible for the reduced proliferation and growth defect. Thus, our study demonstrates that PRC2 has an important regulatory role in lineage-committed tissue cells by suppressing overactivation of multiple signalling pathways.
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Base de dados:
MEDLINE
Assunto principal:
Osso e Ossos
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Fator de Crescimento Transformador beta
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Condrócitos
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Proteínas Wnt
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Subunidade alfa do Fator 1 Induzível por Hipóxia
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Complexo Repressor Polycomb 2
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article