Metal-Catalyzed Annulations through Activation and Cleavage of C-H Bonds.
Angew Chem Int Ed Engl
; 55(37): 11000-19, 2016 09 05.
Article
em En
| MEDLINE
| ID: mdl-27329931
ABSTRACT
The exponential increase in the number of catalytic transformations that involve a metal-promoted activation of hitherto considered inert C-H bonds is promoting a fundamental change in the field of synthetic chemistry. Although most reactions involving C-H activations consist of simple functionalizations or additions, recent years have witnessed an upsurge in related transformations that can be formally considered as cycloaddition processes. These transformations are particularly appealing from a synthetic perspective because they allow the conversion of readily available substrates into highly valuable cyclic products in a rapid and sustainable manner. In many cases, these annulations involve the formation of metallacyclic intermediates that resemble those proposed for standard metal-catalyzed cycloadditions of unsaturated precursors.
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MEDLINE
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En
Ano de publicação:
2016
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Article