Distinct mutations at the same positions of STAT3 cause either loss or gain of function.

Chandrasekaran, Prabha; Zimmerman, Ofer; Paulson, Michelle; Sampaio, Elizabeth P; Freeman, Alexandra F; Sowerwine, Kathryn J; Hurt, Darell; Alcántara-Montiel, Julio C; Hsu, Amy P; Holland, Steven M

Chandrasekaran, Prabha; Zimmerman, Ofer; Paulson, Michelle; Sampaio, Elizabeth P; Freeman, Alexandra F; Sowerwine, Kathryn J; Hurt, Darell; Alcántara-Montiel, Julio C; Hsu, Amy P; Holland, Steven M.

Afiliação

Chandrasekaran P; Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Md.
Zimmerman O; Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Paulson M; Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Sampaio EP; Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Freeman AF; Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Sowerwine KJ; Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Hurt D; Bioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Alcántara-Montiel JC; Department of Molecular Biomedicine, CINVESTAV-IPN, Mexico City, Mexico.
Hsu AP; Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Holland SM; Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Electronic address: smh@nih.gov.

J Allergy Clin Immunol ; 138(4): 1222-1224.e2, 2016 10.

Article em En | MEDLINE | ID: mdl-27345172

Assuntos

Mutação com Ganho de Função; Mutação com Perda de Função; Fator de Transcrição STAT3/genética; Substituição de Aminoácidos; Animais; Células COS; Linhagem Celular; Chlorocebus aethiops; Humanos; Síndrome de Job/genética; Transtornos Linfoproliferativos/genética; Modelos Moleculares; Proteínas Mutantes/química; Proteínas Mutantes/genética; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Fator de Transcrição STAT3/química; Fator de Transcrição STAT3/imunologia; Eletricidade Estática; Domínios de Homologia de src/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Transcrição STAT3 / Mutação com Ganho de Função / Mutação com Perda de Função Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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