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Novel drug design for Chagas disease via targeting Trypanosoma cruzi tubulin: Homology modeling and binding pocket prediction on Trypanosoma cruzi tubulin polymerization inhibition by naphthoquinone derivatives.
Ogindo, Charles O; Khraiwesh, Mozna H; George, Matthew; Brandy, Yakini; Brandy, Nailah; Gugssa, Ayele; Ashraf, Mohammad; Abbas, Muneer; Southerland, William M; Lee, Clarence M; Bakare, Oladapo; Fang, Yayin.
Afiliação
  • Ogindo CO; Department of Chemistry, Howard University, 525 College Street, NW, Washington, DC 20059, United States.
  • Khraiwesh MH; Department of Biology, Howard University, 415 College Street, NW, Washington, DC 20059, United States.
  • George M; Department of Biochemistry and Molecular Biology, Howard University, 520 W Street NW, Washington, DC 20059, United States.
  • Brandy Y; Department of Chemistry, Howard University, 525 College Street, NW, Washington, DC 20059, United States.
  • Brandy N; Department of Chemistry, Howard University, 525 College Street, NW, Washington, DC 20059, United States.
  • Gugssa A; Department of Biology, Howard University, 415 College Street, NW, Washington, DC 20059, United States.
  • Ashraf M; Department of Comprehensive Sciences, Howard University, 260 Locker Hall Street, NW, Washington, DC 20059, United States.
  • Abbas M; Department of Microbiology, Howard University, 520 W Street NW, Washington, DC 20059, United States; The National Human Genome Center, Howard University, 2041 Georgia Avenue NW, Washington, DC 20060, United States.
  • Southerland WM; Department of Biochemistry and Molecular Biology, Howard University, 520 W Street NW, Washington, DC 20059, United States.
  • Lee CM; Department of Biology, Howard University, 415 College Street, NW, Washington, DC 20059, United States.
  • Bakare O; Department of Chemistry, Howard University, 525 College Street, NW, Washington, DC 20059, United States.
  • Fang Y; Department of Biochemistry and Molecular Biology, Howard University, 520 W Street NW, Washington, DC 20059, United States.
Bioorg Med Chem ; 24(16): 3849-55, 2016 08 15.
Article em En | MEDLINE | ID: mdl-27345756
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tripanossomicidas / Trypanosoma cruzi / Tubulina (Proteína) / Doença de Chagas Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tripanossomicidas / Trypanosoma cruzi / Tubulina (Proteína) / Doença de Chagas Idioma: En Ano de publicação: 2016 Tipo de documento: Article