AFAP-1L1-mediated actin filaments crosslinks hinder Trypanosoma cruzi cell invasion and intracellular multiplication.
Acta Trop
; 162: 167-170, 2016 Oct.
Article
em En
| MEDLINE
| ID: mdl-27349187
ABSTRACT
Host actin cytoskeleton polymerization has been shown to play an important role during Trypanosoma cruzi internalization into mammalian cell. The structure and dynamics of the actin cytoskeleton in cells are regulated by a vast number of actin-binding proteins. Here we aimed to verify the impact of AFAP-1L1, during invasion and multiplication of T. cruzi. Knocking-down AFAP-1L1 increased parasite cell invasion and intracellular multiplication. Thus, we have shown that the integrity of the machinery formed by AFAP-1L1 in actin cytoskeleton polymerization is important to hinder parasite infection.
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Base de dados:
MEDLINE
Assunto principal:
Trypanosoma cruzi
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Citoesqueleto de Actina
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Proteínas Adaptadoras de Transdução de Sinal
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Proteínas dos Microfilamentos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article