Low Circulating Levels of Mitochondrial and High Levels of Nuclear DNA Predict Mortality in Chronic Heart Failure.
J Card Fail
; 22(10): 823-8, 2016 Oct.
Article
em En
| MEDLINE
| ID: mdl-27349571
ABSTRACT
BACKGROUND:
Mitochondrial DNA (mtDNA) and possibly nuclear DNA (nDNA) are released as danger-associated molecular patterns during cardiac stress, and may activate several innate immune receptors. The purpose of this study was to investigate the regulation of these danger-associated molecular patterns during human heart failure (HF). METHODS ANDRESULTS:
Plasma levels of mtDNA and nDNA from HF patients (n = 84) were analyzed by reverse transcriptase-polymerase chain reaction and compared with controls (n = 72). Increased levels of mtDNA were found in New York Heart Association (NYHA) I-II and NYHA III-IV. There was evidence of increased nDNA in NYHA III-IV compared with controls and NYHA I-II. Kaplan-Meier analysis revealed higher mortality in patients with high nDNA levels, whereas high levels of mtDNA were associated with survival.CONCLUSIONS:
Plasma levels of mtDNA and nDNA are elevated in human HF associated with increased and decreased mortality, respectively. This study may suggest a rationale for exploring interventions within inflammatory signaling pathways activated by nucleic acids as novel targets in treatment of HF.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Correpressoras
/
Insuficiência Cardíaca
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Mitocôndrias
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article